10 Although little research has been done to determine why specific taste distortions occur, research has provided several explanations (Table 1 10). It is almost impossible to determine if patients have decreased sensitivity (a quantitative problem) or distorted perception (a qualitative problem). Studying taste is a difficult task because taste is entwined with the sense of smell and changes with food texture and temperature. Medications-more than 300 drugs are associated with metallic taste.Trauma (eg, burns, lacerations, surgery, radiation).Underlying medical conditions (eg, diabetes, pernicious anemia, Sjögren’s syndrome, zinc deficiency, and Crohn’s disease).Pregnancy (and accompanying hormonal changes).Metallic taste usually originates from the following causes 5-9: Patients may find 1 alteration especially repulsive: metallic taste. 4 Suspect drug-induced dysgeusia if the problem has temporal proximity to the start of a new drug. Among patients receiving chemotherapy, 38% to 84% reported altered taste, 1-3 and the results of another study show that as many as 11% of elderly patients who take multiple medications experience taste problems. Patients may report changes in taste, a condition known as dysgeusia, ranging from complete loss of taste to an altered or “funny” taste.
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